尼氏體(Nissl body)或稱尼氏小體是分布于神經(jīng)細胞胞質(zhì)內(nèi)的三角形或橢圓形小塊狀物質(zhì)，能被堿性染料如硫堇、亞甲藍、甲苯胺藍和焦油紫等染料染成紅紫色到紫藍色。
尼氏染色液(硫堇法)主要優(yōu)點是操作簡便、染色穩(wěn)定、適用范圍廣，可以用于石蠟組織切片的尼氏物質(zhì)、神經(jīng)元等的染色，尼氏體的存在和消失是神經(jīng)細胞是否受損的重要指標，當發(fā)生腦炎、腦缺血、軸突反應等情況時，尼氏體會發(fā)生溶解甚至消失。    

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標題:Insulin alleviates lipopolysaccharide-induced cognitive impairment via inhibiting neuroinflammation and ferroptosis

成員:Miao Sun, Yang Li, Min Liu, Qingxiao Li, Likai Shi, Xianghan Ruan, Yuting Huo, Zhikang Zhou, Xiaoying Zhang, Yulong Ma, Weidong Mi

論文因子:5 發(fā)表期刊:EUROPEAN JOURNAL OF PHARMACOLOGY pmid:37479016

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標題:SM22α Deletion Contributes to Neurocognitive Impairment in Mice through Modulating Vascular Smooth Muscle Cell Phenotypes

成員:Xin Xu, Xiao-Qin Liu, Xin-Long Liu, Xu Wang, Wen-Di Zhang, Xiao-Fu Huang, Fang-Yue Jia, Peng Kong, Mei Han

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標題:Berberine modulates gut microbiota to attenuate cerebral ferroptosis induced by ischemia-reperfusion in mice

成員:Xinyu Wang, Jiamin Zhang, Sisi Wang, Zhengyang Song, Hongxia Sun, Fangquan Wu, Xiaohui Lin, Keke Jin, Xiaofeng Jin, Wantie Wang, Qiongqiong Lin, Fangyan Wang

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標題:Icariin reduces cognitive dysfunction induced by surgical trauma in aged rats by inhibiting hippocampal neuroinflammation

成員:Wang Lifeng, Peng Guanfa, Chen Li, Guo Mingling, Wang Bingyu, Zhang Yunmeng, Zhou Jianshun, Zhong Maolin, Ye Junming

論文因子:3 發(fā)表期刊:Frontiers in Behavioral Neuroscience pmid:37351155

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標題:Ozone rectal insufflation mitigates chronic rapid eye movement sleep deprivation-induced cognitive impairment through inflammation alleviation and gut microbiota regulation in mice

成員:Cheng Jie, Williams John P., Zhou Li, Wang Peng-Cheng, Sun Li-Na, Li Rui-Hua, An Jian-Xiong

論文因子:2.9 發(fā)表期刊:Medical Gas Research

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尼氏染色液(硫堇法)

尼氏染色液(硫堇法)